Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa

In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase ( OAC ) from Cannabis sativa, involved in cannabinoid biosynthesis, is the only known plant polyketide cyclase. In addition, it is the only functionally characterized plant α+β barrel ( DABB ) protein that catalyzes the C2–C7 aldol cyclization of the linear pentyl tetra‐β‐ketide CoA as the substrate, to generate olivetolic acid ( OA )....