NMDA Receptor and Schizophrenia: A Brief History
Abstract
Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schizophrenia in normal subjects that placed the "NMDA receptor hypofunction hypothesis" on firm footing. Additional support came from...
Paper Details
Title
NMDA Receptor and Schizophrenia: A Brief History
Published Date
Sep 1, 2012
Journal
Volume
38
Issue
5
Pages
920 - 926
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Notes
History